B: A schematic showing the dividing (Ki67 +ve) cell types in the adult hippocampus. The Anatomyand Physiology sections highlight the features relevant to understanding hippocampal function at the level of systems and cognitive neuroscience. In this article, we describe aspects of hippocampal anatomy, physiology, and function. Their expression varied with respect to different astroglial subpopulations (GluT and GluR cells) of the mouse hippocampus. Finally, the highly ordered structure of the hippocampus and its significant capacity for reinnervation makes the hippocampus a favorite experimental model for the analysis of operational principles of neuronal circuitry and for the study of brain plasticity and regenerative capacity. A: Coronal section of an adult mouse brain at the level of the hippocampus stained for DAPI (white). The hippocampus thus occupies a prominent place in studies of brain function at multiple levels. CPEBs (2, 3 and 4) were detected in distinct astroglial subpopulations of mouse hippocampus by immunofluorescence, single cell RT-PCR and nonradioactive in situ hybridisation (ISH). In particular, the hippocampal formation as compared with other brain structures has the most protracted span of neurogenesis, which gives an opportunity not only to study certain stages of neurogenesis in detail but to investigate them experimentally using various effects. The hippocampus (Latin for seahorse) is a structure in the medial temporal lobe, lining the temporal horn of the lateral ventricle. Being a relatively simple part of the cerebral cortex with respect to its internal structure, the hippocampal formation contains various subregions with different organization and rates of development. Such interest in the hippocampus is caused both by its functional role, which is believed to be learning and memory, and by unique peculiarities of the hippocampal organization and development (see reviews in the two-volumed book edited by Isaacson and Pribram 1975, 1985). The hippocampus is a highly organized structure in the brain that is a part of the limbic system and is involved in memory formation and consolidation as well as the manifestation of severe brain disorders, including Alzheimers disease and epilepsy. The hippocampus is one of the most intensely studied formations of the brain.
Advances in Anatomy Embryology and Cell Biologyīook series (ADVSANAT, volume 122) Zusammenfassung